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Of note, the estimated 25% 30% of HIV-infected individuals who are unaware of their HIV status represents a major unresolved challenge.
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Sepsis continues to be a major unresolved medical challenge of the present.
Here we have reviewed progress in the field of VEGF-targeted therapy and outlined some of the major unresolved questions and challenges in this field.
With this kind of internal, unresolved challenge, you have to take the time, and the environment".
"A major unresolved issue is how to fund this effort," Mr. Billington said.
But it needed "strong leadership" because there were "major unresolved green belt issues".
Sarah's major unresolved loss is that of her childhood best friend, Jennifer Jones.
A major unresolved issue is how quickly newly arrested Afghans should be turned over.
There are major unresolved differences including over the future of Mr Assad.
There are also major unresolved issues over the Tube Lines staffing arrangements for the night tube and over performance-related pay.
Major unresolved issues remain nosologic.
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