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Special cases were then proved, but only in 2006 was the first generally convincing proof published of the Poincaré conjecture in three dimensions, which was a major unresolved part of Thurston's geometrization conjecture.
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Therefore, a major unresolved question for the majority of SUMO substrates is exactly how SUMOylation is initiated and regulated.
The adaptive function of sex, today, remains a major unresolved issue in biology.
One major unresolved obstacle to European bank merger and acquisition activity is the role of national regulators.
Fouling is a major unresolved problem in heat transfer.
However, there are still several major unresolved issues that need to be addressed.
A major unresolved question is the basis for this selective neuronal vulnerability.
"A major unresolved issue is how to fund this effort," Mr. Billington said.
But it needed "strong leadership" because there were "major unresolved green belt issues".
Sarah's major unresolved loss is that of her childhood best friend, Jennifer Jones.
A major unresolved issue is how quickly newly arrested Afghans should be turned over.
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