Therefore, a major unresolved question for the majority of SUMO substrates is exactly how SUMOylation is initiated and regulated.
With the human condition in mind, we then review mouse models of AD, analyze reports of sex differences and hormone effects in male and female mice that model AD, raise major unresolved questions, and offer a research framework that incorporates human reproductive aging for future studies aimed at translational discoveries in the important area of sex and hormone biology.
To this end, we highlight advances in AD and in sex and hormone biology, discuss what these advances mean for merging the two fields, review the current mouse model literature, raise major unresolved questions, and offer a research framework that incorporates human reproductive aging for future studies aimed at translational discoveries in this important area.
Another major unresolved question is the normal concentration of endogenous vasoinhibins in the human circulation.
A key benefit from bridging between human medical genomics and human evolutionary genomics is reciprocal illumination of answers to two of the major unresolved questions in biology: how we evolved, and why we fall victim to cancer, schizophrenia, type 2 diabetes, and a suite of other polygenic, human-concentrated diseases.
Sarah's major unresolved loss is that of her childhood best friend, Jennifer Jones.
A major unresolved issue is how quickly newly arrested Afghans should be turned over.
"A major unresolved issue is how to fund this effort," Mr. Billington said.
There are major unresolved differences including over the future of Mr Assad.
But it needed "strong leadership" because there were "major unresolved green belt issues".
