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The major functional difference between NANOG and NANOGP8 is at the level of gene expression.
The neoplastic transforming activity is the role of the mt-PCPH that represents the major functional difference between the normal protooncogene and mutated active oncogene.
Thus, a major functional difference between OCRL and INPP5B seems to be the involvement of OCRL, but not of INPP5B, in clathrin-mediated endocytosis.
The major functional difference between the normal NTPDase5 and the mt-PCPH oncoprotein is that the former provides lower levels of protection against apoptotic agents, including chemotherapeutic drugs, and radiation than the latter.
The alternative splicing of this exon suggests a major functional difference between the two TACC2 isoforms, TACC2s and TACC2l [ 3], as well as a significant difference between TACC2 and its closest TACC family relative, TACC1.
Another major functional difference in the three TRs as compared to Goa1p is that they negatively regulate genes associated with cell wall and cell integrity while Goa1p positively regulates this gene cluster including the signaling transduction pathway MAPK CEK1 and CHK1[ 25, 25].
Similar(53)
There is presently no consensus regarding whether differences in ion channels and receptors, that constitute the major functional differences between neurons, are subject to active regulation at the transcriptional level.
While the pathway completeness-based analysis can highlight major functional differences between metagenomes and reference genomes, it does not account for the abundance of specific genes, and thus does poorly in differentiating relatively similar communities (e.g. the three archaeal communities).
This suggests that there are no major functional differences relating to cell movement between the exogenous and endogenous proteins.
The major functional differences between Sti1 and Hop observed in this study are conveyed by phosphorylation which occurs almost exclusively at unique sites.
In spite of the large difference in genomic occupancy, detailed analysis of genes associated with GATA3 binding failed to identify any major functional differences between binding profiles in T47D and MCF7 cell lines (Additional file 1: Figure S6-S10).
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