Sentence examples for major functional impairment from inspiring English sources

Schizophrenia is a severe mental illness that causes major functional impairment.

Patients with advanced deformity and major functional impairment will be counselled to wait until the age of 13.

ICU survivors recovering from a prolonged illness often have muscle weakness and major functional impairment.

Progressive attrition in the joint parts not yet replaced (e.g. partial replacement of knee joints) or major functional impairment after joint replacement may also indicate a change.

However, when achieving clear surgical margins will require major functional impairment of the extremity, a radical surgical approach should be weighed for the patient in each case.

Thus, patients had to have major functional impairment of any duration associated with a rise in transaminases of at least 3 times the upper limit of normal, or a similar rise in alkaline phosphatase, or both.

Compared to the iliac wing, wide resection is only possible with major functional impairments (case 12) and intralesional procedures often result in secondary complications such as arthritis (case 10) or problems related to cementation.

OA is a major contributor to functional impairment and loss of independence in older persons [ 2].

Additionally, perturbed stability of these regulatory proteins is a major cause for functional impairment.

Osteoarthritis (OA) is a major cause of functional impairment and disability among the elderly [ 1], yet current therapies predominantly target symptoms rather than providing prevention or curative treatment.

Osteoarthritis (OA), the most common form of arthritis, is a major contributor to functional impairment and loss of independence in older persons.