The most important functional difference between mESCs and EpiSCs is the striking inability of EpiSCs to form chimeras upon morula or blastocyst injection [1], [2].
The most important functional difference within all isoforms results from the insertion of three additional amino acids (KTS) by splicing events: the WT1 (-KTS) isoform acts as a transcription factor, while WT1 (+KTS) is mainly involved in RNA processing [32], [33].
An important functional difference, however, exists between the two receptors.
Many of the differentially methylated genes were related to developmental processes and immune response, perhaps reflecting an important functional difference between normal and trisomic tissues.
An important functional difference between TKI and EGFR antibodies lies in the antibodies' ability to attack cancer cells through a combination of mechanisms.
An important functional difference between myosin and kinesin, however, is that these motors attach and detach from their partner filaments at different points in the ATPase cycle.
Therefore, it is possible that the wavelength difference between UVS and VS type pigments might not be the only, or the most important, functional difference between them.
These phenotypic changes are associated with an important functional difference: semi-mature SP thymocytes are susceptible to apoptosis upon TCR stimulation, whereas mature SP thymocytes are not and respond instead by proliferating (Sprent and Kishimoto, 2002; Weinreich and Hogquist, 2008).
