Sentence examples for major functional isoform from inspiring English sources

VEGF164/165 is the major functional isoform that contains the heparin-binding domain.

We show that 4E-BP1 is a major functional isoform in the pain pathway, where it represses translation of neuroligins in the spinal cord.

The major functioning isoform is ΔNp63 α.

As mentioned previously, ∆Np63 is the only major isoform expressed and the isoform that plays a major functional role in FaDu cells.

Both the longer and shorter isoforms contain the major functional domains of the protein, including the GTPase domain, and are functionally active in biochemical assays [ 29, 36].

The alternative splicing of this exon suggests a major functional difference between the two TACC2 isoforms, TACC2s and TACC2l [ 3], as well as a significant difference between TACC2 and its closest TACC family relative, TACC1.

These data are consistent with results from a recent RNA-seq analysis of the developing mouse epidermis [ 53] and from p63 isoform-specific knockout experiments that demonstrated the major functional role of ΔNp63 in the epidermis [ 54, 55].

As can be seen in Figure 8, (the position of domains in the longest DYNC1I1 and DYNC1I2 isoforms are shown in Table S3) the exon structure for these major functional domains is similar between the IC1 and IC2 proteins.

It has major functional and socioeconomic impacts.

Major functional groups are briefly reviewed below.

Another major functional category was enzyme regulation.