Sentence examples for major functional consequence from inspiring English sources

Together the lack of significant effect of T1410 mutation on dimerization and kinase activity indicate that it does not have a major functional consequence on LRRK2's phosphorylating activity towards other substrates.

The major functional consequence associated with uridylation is to trigger RNA degradation but is not limited to it.

Sequentially, autoantibodies bind to complement fragments, which have a major functional consequence to cause tissue injury, especially in the kidney [ 39, 40].

The results of the present study indicate that a major functional consequence of PTP inhibition is hyperphosphorylation of some important cellular signalling proteins, thereby providing a novel mechanism by which MPO-derived HOSCN can modulate cell signalling and survival events.

In a second group of constructs, namely, 4, 5(b), 6, 7, 10, and 11(b) as well as NT and CT, the epitope insertion had no major functional consequence, with transport rates similar or superior to those detected in the positive control (7−12-fold stimulation above background).

SNHL may appear after severe brain injury or temporal bone trauma and potentially have major functional consequences.

There are two major functional consequences of this inserted position of the coiled coil.

Schizophrenia and bipolar disorder are examples of some chronic illnesses for which there exists a high risk of relapse associated with major functional consequences.

By comparing histone modification patterns in normal mucosa and tumors, we found that alterations predicted to have major functional consequences were quite rare.

Within ORFs, errors may result in frame-shifting and premature stop codons; those that conserve the ORF change the length of the protein, often (but not always) without major functional consequences.

By comparing normal and tumor colon samples, it was observed that some regions, either shared or unique to one patient, showed transitions in the chromatin states that would suggest major functional consequences (i.e. from normal H3K4me3 to tumor H3K27me3 or vice verse).