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However, the development of antimicrobial resistance in this context can have major clinical consequences.
However, pleural or ascitic effusions do not always indicate advanced or metastatic malignant disease, with major clinical consequences.
We report a case in which Coccidioides immitis produced a biofilm on a medical device, resulting in a persistent infection with major clinical consequences for the patient.
Thus, it was possible to develop a rapid referral system for a condition, which, although uncommon in primary care, has major clinical consequences if not diagnosed.
Has the virus settled down in a local reservoir for years without major clinical consequences before reemerging thanks to favorable conditions?
Our data also support the hypothesis that malaria might cause re-activation of HHVs in some children but without major clinical consequences.
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Since hip fractures are highly prevalent in this population, even a minor excess risk may cause great numbers of hip fractures, with major clinical and economic consequences.
Long-acting injectable antipsychotic drugs were developed to become a therapeutic option especially for those patients where nonadherence is a major clinical concern, with consequences of subsequent relapse episodes and rehospitalizations [ 46, 122, 123].
This misdiagnosis can lead to major clinical, therapeutic and ethical consequences.
The finding that in 16% of cases the reported incubation period exceeded 10 days has major clinical and public health consequences.
Furthermore, since the ultimate clinical consequences of major bleeding and venous thromboembolic events might be different (i.e. their associated mortality), we incorporated in the analysis a reference range of RBAT values derived from the case fatality rate-ratios of thrombosis and bleeding.
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