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The major clinical effects caused by the venom of this species include vomiting, abdominal pain, diarrhoea, and dizziness.
The major clinical effects in humans diarrhoea and vomiting typically develop during the second week of radiotherapy (cumulative radiation dose of 15 20 Gy).
Restricting ciguatera cases to only those with moderate or major clinical effects resulted in rate ratios of similar values, although confidence intervals were wider (and included the null) because the number of calls was reduced by 65% (see Supplemental Material, Table S5).
Macrovascular disease, characterized by atherosclerotic changes in large blood vessels, is the major cause of morbidity and mortality (80%) in type 2 DM [ 2]; its major clinical effects are seen in the coronary arteries (angina, myocardial infarction), lower extremities (gangrene), and carotid arteries (stroke).
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With the recently legislated "breakthrough product" definition in the U.S., it may be possible to plan a single trial for registration purposes to confirm a major clinical effect observed in phase I.
A total of 412 calls (37.4%) resulted in moderate or major clinical effect (including death).
Another major clinical effect of SST is immuno-modulatory activity in diverse diseases [ 41, 42].
Despite the high expectations for accurate forecasting of disease based on genetic information, and the marketing of direct-to-consumer genetic tests, 2 it seems increasingly less likely that genes will have a major clinical effect on the prognosis of common complex diseases.
The major clinical side effects of this drug are gastrointestinal in nature.
Combined RM and PP led to the highest increase in PaO2/FiO2 ratio without major clinical side effects.
Despite absence of major clinical side effects a potential risk remains that transplantation of MSC may harbor some tumorigenic potential - especially in autologous transplant settings.
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