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None of these harms had major clinical impacts in any of the studies.
While cellular competition is the issue most often addressed, other types of interactions, with possible major clinical impacts have also been observed.
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This resulted in a change from potential radical surgery to chemotherapy a major clinical impact.
This resulted in a change from potential chemotherapy to radical surgery a major clinical impact.
Revised diagnosis (RDx) was associated with major clinical impact in 57.1% of reports, but few patients experienced increased morbidity, and none increased mortality.
FDG PET-CT had a major clinical impact in 21 cases (41.2 %), of which 18 examinations were performed in patients with proven or suspected stage IV MM.
A major clinical impact was defined as a change in treatment plan, e.g. radical surgery to systemic chemotherapy resulting from identification of additional sites of disease or by characterisation of indeterminate findings on prior CECT imaging.
A major clinical impact was defined as a change in treatment plan resulting from identification of additional sites of disease or by characterisation of indeterminate findings on prior imaging.
Because of the major clinical impact of KRAS status, an observational study has been designed in France, focusing on the ability to perform KRAS testing between october 2008 and october 2009.
Similarly, two cases of major clinical impact where FDG PET-CT was used to determine eligibility for entry into a chemotherapeutic clinical trial, illustrate the unique options available for treatment via a tertiary centre SSMDT and also the fact that patients with inoperable late-stage MM undergoing chemotherapy would not routinely undergo FDG PET-CT examination.
Although the impact of revised diagnosis (RDx) was deemed to have a major clinical impact in 57.1% of reports, few patients experienced increased morbidity, and none were perceived to have experienced increased mortality or altered long-term outcome at the time of EP follow-up.
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