Sentence examples for major clinical implications from inspiring English sources
The identification of skeletal maturity, with particular reference to the onset of the pubertal growth spurt, has major clinical implications when dealing with orthodontic treatment in growing subjects, especially when dentoskeletal disharmonies are present [1, 2].
In this regard, the identification of skeletal maturity, with particular regard to the onset of pubertal growth phase, would have major clinical implications when dealing with orthodontic treatment in growing patients with skeletal class II malocclusion [12 14].
Heat-mediated ELISA (HELISA) technique has been reported to shorten ELISA timings and has major clinical implications in diagnostic field [Bora U, Kannan K, Nahar P. Heat mediated enzyme linked immunosorbent assay. J Immunol Methods 2004; 293: 43–50].
Given the challenge in treating ER− breast tumors and its inherent poor prognosis, the use of Noscapine in combination Doxorubicin will have major clinical implications for the treatment of ER− breast cancer.
This conventional concept of GRP94 as protein folding chaperone is updated by the discoveries that GRPs promote tumor proliferation, metastasis, drug resistance, and immunotherapy, which have major clinical implications in the prognosis and treatment of cancer [3].
This finding has major clinical implications.
The major clinical implication of these studies relates to the role of vSMC proliferation in cardiovascular disease.
A major clinical implication is that seasonal variation of 25(OH D can directly influence the diagnosis of vitamin D insufficiency and deficiency.
The major clinical implication of our results is that the disease management program probably does not reach a considerable amount of higher risk patients.
Unclear or misleading laboratory reports may have major clinical implication, as the presence or absence of a pathogenic MMR mutation typically impacts the patients' management process.
The major clinical implication of the present report is the increased potential for treatment failure with most antibacterial drugs currently recommended to empirically treat community-acquired respiratory tract infections (30, 31).
