Sentence examples for main pathways activated from inspiring English sources

Two of the main pathways activated by EGF binding to the EGF receptor are the mitogen-activated protein kinase (MAPK) pathway and the phosphoinositide 3-kinase (PI3K) pathway [ 17]; both pathways have been shown to be involved in EGF-mediated epithelial cell migration [ 18- 20].

Two of the main pathways activated by HER4 are the MAPK pathway and the PI3K/Akt pathway, the latter specific for CYT1.

There are three main pathways activated upon UPR induction, including transcription factor 6 (ATF6), PKR-like ER kinase (PERK), and inositol-requiring kinase 1 (IRE-1) [ 76].

In Figure 4 are schematically summarized the main pathways activated during hyperglycaemia and low insulin level inducing diabetes-associated vascular diseases.

Herein, we also attempt to afford an overview of the complex crosstalk between autophagy and DNA damage response (DDR), focusing on the main pathways activated upon ROS and RNS overproduction.

In addition, HBEGF signalling through EGF receptors was identified as a main pathway activated by mechanical stress induced by airway constriction (5).

These receptors are mainly involved in cell proliferation and survival through activation of PI3K-Akt [ 11], STAT3 [ 12], and Ras-Raf-MAPK signaling pathway, with the latter described as the main pathway activated by EGFR [ 13].

VEGFR2 is the receptor that initiates the main signaling pathways activated by VEGF.

The PKB/AKT pathway is one of the main signaling pathways activated by VEGFR2 [ 8].

Here we summarized previous studies from our and other laboratories exploring the cytotoxic effect of drugs inhibiting the main prosurvival pathways activated in PEL cells.

Some of the main alternative pathways activated by TGF-β in the context of cancer progression are the p38 and c-Jun N-terminal kinase (JNK), pathways belonging to the MAPK family [ 25].