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It was revealed that the main genes activated in radish taproot, were predominately involved in basic physiological and metabolic processes, biosynthesis of secondary metabolites, signal transduction mechanisms, and other cellular components and molecular function related terms based on their matches in the GO, COG and KEGG databases.
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Oncogenic genes activated by such epigenetic change represent potential therapeutic targets.
The main genes that were activated following the exposure of pear leaves to salt were predominately involved in basic biological processes, biosynthesis of secondary metabolites, signal transduction mechanisms, and other cellular components and molecular functions (based on their matches in the COG, GO and KEGG databases).
Our observations show that in the RAW 264.7 cell line the main activated genes were the ones controlled by the STAT1-STAT1 homodIRF1 (IRF1 and SOCS1) and containing GAS elements in their promoter region.
Casps are the main proteases activated during apoptotic signaling.
Based on the statistical stability of the main gene expression regions, a regulation mechanism is proposed where genes in early regions activate genes in corresponding later regions, while genes in adjacent regions repress one another (Fig. 21).
Our analysis targeted two main classes of genes: 1) upstream regulatory genes that may be spatially regulating optix expression, and 2) genes differentially activated downstream of optix to play a role in the differentiation of pigment-bearing scale cells.
Here we summarize the main pathway clusters activated by PHEO- and PGL-susceptibility genes: pseudohypoxic, kinase, and Wnt signaling.
uPAR gene is upregulated by the activated RAS signaling pathway, the main signaling pathway activated in colon cancer [ 72].
The main signaling pathways activated by IL6 are the STAT3- and MAPK-pathways leading to altered gene expression, which among others comprise genes related to metastasis, apoptosis and proliferation [ 26].
It turned out that introducing the new genes could activate cancer genes.
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