Sentence examples for principal pathways activated from inspiring English sources

The two principal pathways activated by IL-1β and TNF-α are the NF-κB and mitogen-activated protein kinase (MAPK) pathways, and the roles of both in the pathogenesis of destructive arthritis have been reported [ 9, 10].

The two principal pathways activated by IL-1 and TNF-α are the NF-κB and AP-1 pathways [ 10, 18], which induce MMP-9 expression.

Calpain-, ubiquitin- and caspase- mediated protein degradation are the principal proteolytic pathways activated in several pathologies, leading to myofiber degeneration, and impaired muscle regeneration.

A principal problem is the typical simultaneous activation of pathways activated by Ca2+ store depletion and by second messenger mechanisms such as generation or depletion of lipid mediators.

The principal apoptotic pathway activated by many anti-cancer drugs is the Fas apoptotic pathway.

The signaling adaptors and pathways activated by TNF superfamily.

The principal intracellular signaling pathway activated by these proteins has been elucidated in recent years.

These studies define a pathway by which overexpression of Pdx-1 activates islet cell proliferation that is distinct from and additive to a pathway activated by Nkx6.1.

Two principal pathways of caspase activation have been recognized [ 11– 13].

Two principal pathways are involved in apoptosis: a pathway that is directly activated by death receptors and a pathway that involves mitochondria.

The insulin-signaling pathway activates a powerful gene regulator that controls many genetic pathways, including some that govern metabolism.