Sentence examples for major pathways activated from inspiring English sources

This is one of the major pathways activated within epithelial cells by the combination of TGFβ and matrix rigidity [99].

The major pathways activated by ObRl are the classic cytokine JAK2/STAT3 pathway, the Ras/ERK1/2 signaling cascade, and the PI-3K/Akt/GSK3 growth/anti-apoptotic pathway [ 12].

One of the major pathways activated downstream of outside-in signalling in mammalian cells is the PI3 kinase-Akt pathway, which is necessary for the anchorage-dependent survival of the cells (Somanath et al, 2007).

The major pathways activated by EGFR-TK are the Ras-Raf-MEK-ERK pathway (leading to cell growth), the mTOR pathway (leading to protein synthesis), and the PI3K/Akt pathway (leading to cell survival by blocking apoptosis).

We focused on the activation of the NF-κB pathway as this is the major pathway activated by EDA [ 22].

This suggests that XBP-1 splicing may not be a major pathway activated by suspension growth conditions or that it may be activated later, when the vast majority of the cells are committed to apoptosis.

Similarly, the PI3K pathway, a major pathway activated by FGFRs, has been demonstrated to promote senescence when hyperactivated (31).

Indeed, activation of the ERK pathway in osteoblasts is obligatory for the action of galectin-8 as an inducer of osteoclastogenesis, implicating this signaling pathway as being the major pathway activated downstream of galectin-8.

The major signaling pathways activated in cancer, including Ras, Raf, PI3K, and AKT, enhance RNAP-III activity, whereas several tumor suppressors, including retinoblastoma, PTEN, p53, and BRCA1, decrease RNAP-III activity [ 35].

Insights into the mechanisms whereby PTK6 induces anoikis resistance were provided by high throughput protein arrays and subsequent analyses, which demonstrated that loss of PTK6 had broad effects on the major signaling pathways activated by IGF-1R as well as IGF-1R itself.

On EGF binding, the major signalling pathways activated are the MAPK and AKT cascades (Citri and Yarden, 2006).