Future improvements will include the incorporation of targeted imaging contrast agents to improve specificity for imaging tumours.
A series of pyrazolo-pyrido-diazepine dione analogs demonstrated to be particularly amenable to lead optimization through a couple of cycles in order to improve specificity for isoforms Nox4 and Nox1 and had excellent pharmacokinetic parameters by oral route.
In accordance to earlier reports, by combining CRP and WCC measurements we could not further improve specificity for the diagnosis of bacteremia [ 6, 25].
Later, the myocardial band (MB) isoform of CK (CK-MB) and serum myoglobin levels were utilized to improve specificity for cardiac damage and reduce the time to diagnosis.
Therefore, to improve specificity for active kala-azar case confirmation, we used an alternative cutoff of 10 standard deviations (strong seropositive) for 2002 serosurvey data.
To improve specificity for detecting antibody for H9N2 over that of the hemagglutination-inhibition antibody assays used previously (3 ), we used a combination of confirmatory tests and an adsorption step to reduce cross-reactivity with antibodies to other influenza viruses.
