Sentence examples for enhanced specificity for from inspiring English sources

Bisubstrate analogs have the potential to provide enhanced specificity for protein kinase inhibition and tools to understand catalytic mechanism.

Using a structure-guided approach, we designed an O13 mutant with further enhanced specificity for H-trisaccharide.

These structures allow for the construction of models of DntR in complex with salicylate (Kd≅4 μM) and 2,4-dinitrotoluene that provide a basis for the design of mutant DntR with enhanced specificity for dinitrotoluenes.

"Door-opening" conformational changes by phenylalanines within the hydrophobic pocket are revealed during lipid encapsulation by new crystal structures of bona fide apo-GLTP and GLTP complexed with N-oleoyl-glucosylceramide. The development of "engineered GLTPs" with enhanced specificity for select GSLs provides a potential new therapeutic approach for targeting GSL-mediated pathologies.

It seems therefore attractive to design clustered TRAIL variants with enhanced specificity for tumor tissue.

Because of the mutation heterogeneity of lung cancer cells associated with acquired drug resistance, the search for novel anticancer agents with an enhanced specificity for cancer cells remains an urgent need in order to increase the potency of chemotherapy [ 3].

Using four shapes of nanoparticles (nanospheres, nanostars, nanocubes, and nanorods), we demonstrate that each shape provides a unique set of responses in the presence of different bacteria, which can be exploited for enhanced specificity of the biosensor.

Ongoing technical developments and optimization for acquisition of similar data at 7 T magnetic field are also presented, targeting higher spatial resolution, enhanced specificity of functional imaging signals, mitigation of the inhomogeneous radio frequency (RF) fields, and reduced power deposition.

Usually, the transporters from the same families, and, for glucose and amino acids, sometimes the same transporters, are expressed at both sides of epithelial cells, supporting enhanced specificity of nutrient transport processes.

With a quantitative understanding of dual-ligand liposome binding, the insights gained from this study can inform rational design of modular heteromultivalent nanoparticles for enhanced specificity to target tissue for the creation of more effective cancer treatments.

Previous research with LNA in other applications has shown interesting properties for molecular hybridization including enhanced specificity in allele-specific PCR.