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Liquid-based cytology (LBC) combined with reflex detection of HR-HPV types in cases of minor cytological abnormalities probably provides increased sensitivity and increased specificity for the detection of high-grade cervical lesions, when used in population-based screening.
In contrast, tumor cells and tumor DNA found in the lungs are most likely from lung tumors or lung metastases and therefore lead to an increased specificity for lung cancer due to the choice of a lung specific analyte.
In addition, the V148W, V148L, A200I, and V148L/A200I variants had increased specificity for catechol.
Wild-type CotA oxidizes ABTS ABTSS = diammonium 2,2′-azino-bis 3-ethylbenzothiazoline-6-sulfonate 2,2′-azino-bis 3-ethylbenzothiazoline-6-sulfonate 2,2′-azino-bis 3-ethylbenzothiazoline-6-sulfonate 2,2′-azino-bis 3-ethylbenzothiazoline-6-sulfonate 2,2′-azino-bis 3-ethylbenzothiazoline-6-sulfonate 2,2′-azino-bis 3-ethylbenzothiazoline-6-sulfonate
As expected, adjustment for verification bias decreased sensitivity and increased specificity for all tests.
DHE has increased specificity for superoxide compared with other dyes which are more general reactive oxygen species probes.
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Screening of these loop-randomized libraries against αvβ3 integrins resulted in peptides that retained high affinities for αvβ3 and had increased specificities for αvβ3 over αiibβ3 integrins.
By merging the raw junctions and then setting the cutoff according to the overall exon coverage, we are aiming at improving sensitivity for shared junctions and to increase specificity for the sample-specific junctions.
A new generation of small-molecule SAP/MAPK inhibitors that demonstrate increasing specificity for each of the JNK, ERK and p38 kinase isoforms has shown promise in animal studies and could eventually prove effective for treating human diseases.
In addition, we used a cutoff score of ≥16 to increase specificity for depression (21).
Subsequent studies explored lower MoCA cutoff scores to increase specificity for detection of cognitive impairment as compared to HCs.
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