This finding may enable the rational design of novel peptide analogs that demonstrate enhanced specificity for α6∗ nAChR subunit interfaces and provide a means to better understand nAChR structural determinants that modulate brain dopamine levels and the pathophysiology of Parkinson's disease.
Possibilities to enhance specificity of the test should be explored.
Two pairs of specific primers, ENF779/ ENR779 and ENF176/ENR176 were designed from the amplicon described above for a nested PCR protocol to enhance specificity and sensitivity for detection of the new microsporidian (Table 1).
Real-time PCR procedures for detection of SRE were developed to enhance specificity, reliability and for quantification of the target pathogen.
On the basis of work with polyamides and heterocyclic diamidines, such as DB293, dimer-forming compounds have been used to enhance specificity and affinity for wider DNA minor grooves with GC base pairs.
Furthermore, novel AAV library principles like sequence evolution by error-prone PCR [62] and DNA shuffling [63] might enhance specificity and efficiency if used for in vivo selection.
Notifiable diseases based on other types of tests (e.g., serology for syphilis) would require clinical criteria to enhance specificity (information not available by electronic reporting).
All the mutants show enhanced specificity constants for CB1954, and, apart from N71S, the enhancement is selective for CB1954 over nitrofurazone.
Hox transcription factors can co-operatively bind with PBC-class co-factors, enhancing specificity and affinity for their appropriate binding sites.
