Sentence examples for achieve specificity for from inspiring English sources

To achieve specificity for these various functions, β-glucosidases must bind to a wide variety of aglycones, in addition to the glucose of the substrate.

Most protein kinases achieve specificity for their protein targets by recognizing sites that are more extensive than the single residue that is to be modified (47).

To achieve specificity for different artemisinin derivatives, which differ in R-groups at position 12, conjugation of the artemisinin derivatives to a carrier protein at the opposite position is needed.

In this study, the Roman snail (Helix pomatia) Cu-loaded and Cd-loaded isoforms (HpCuMT and HpCdMT) were used as model molecules in order to elucidate the biochemical and evolutionary mechanisms permitting pulmonate MTs to achieve specificity for their cognate metal ion.

For example, a PRC1 variant complex containing RYBP and lacking chromobox domain-containing proteins appears to be involved in this process but it is unclear how RYBP would achieve specificity for polycomb targets as it has no inherent chromatin or DNA binding specificity (Arrigoni et al., 2006; Neira et al., 2009; Tavares et al., 2012; Gao et al., 2012; Hisada et al., 2012).

In order to evaluate how E. coli EF-Tu achieves specificity for other aa-tRNAs, koff values for each of the 19 mutant EF-Tu proteins bound to E. coli Tyr-tRNATyr were determined (Table 1).

As for the interaction topologies, the mode of binding and the way to achieve specificity are often specific for each family.

Soluble proteases, on the other hand, achieve specificity by looking for proteins with a particular sequence of amino acids.

In summary, we propose that high intrinsic nucleosome occupancy of regulatory regions can provide multiple mechanisms for achieving specificity of gene regulation in large genomes, and that it may in fact be a hallmark of genome organization in complex eukaryotes.

Thank you for choosing to send your work entitled "Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics" for consideration at eLife.

> Figure 3 (left and middle panels) shows the achieved specificity and sensitivity for all defined feature sets.