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Correction of ceramide and sphingosine levels can be achieved by inhalation of functional acid sphingomyelinase inhibitors, recombinant acid ceramidase or by normalization of β1-integrin expression and subsequent re-expression of endogenous acid ceramidase.
This measurement provides an estimate of net endogenous acid production (NEAP).
Net endogenous acid production (NEAP) was calculated according to the algorithm from Remer and Manz [ 44, 45].
The estimate of endogenous acid production has been further simplified by considering only protein and K intakes.
Fifth, acidosis-related markers such as arterial blood gas, arterial pH, and endogenous acid production were not measured.
It has been reported that the capacity to excrete net endogenous acid decreases significantly with age [ 20].
Similar(34)
In addition, there is no indication that production of endogenous acids is increased as the patients did not develop any clinical symptoms of hypoperfusion.
To avoid possible interference from naturally occurring endogenous acids and quantitation errors 3- 4-chlorophenyl) propionic acid was chosen as an internal standard.
This can be, e.g., be found in septic patients leading to the production of lactic acid, nor diabetic ketoacidosis or any other clinical state and consequently to the production of endogenous acids.
In principle, metabolic acidosis can develop in three different ways: (1) addition of exogenous acids (in this case either infusion of cationic AA or the acidity of the AA infusion itself), (2) accumulation of hydrogen ions as result of inadequate renal excretion due to chronic renal insufficiency, and (3) increased production of endogenous acids (e.g., lactic acidosis or ketoacidosis).
Electrolytes also stimulate thirst, promote solute absorption in the gastrointestinal (GI) tract [1], [2], [3], and buffer endogenous acids [5].
Related(20)
endogenous hydrogen
respective acid
innate acid
national acid
endogenous precipitation
own acid
local acid
endogenous deposition
spontaneous acid
communal acid
native acid
intrinsic acid
underlying acid
localized acid
endogenous nature
endogenous stress
endogenous retrovirus
endogenous emergence
endogenous inhibitor
endogenous decay
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