Sentence examples for underlying acid from inspiring English sources

The intracellular mechanism underlying acid secretion appears to involve Protein Kinase A (PKA) and Protein Kinase C (PKC) [ 21, 22], as a study implicated PKA as a negative regulator of acid secretion in rat osteoclasts [ 23], and another study showed effects with different tyrosine kinase inhibitors in avian osteoclasts [ 24].

There is therefore a need to identify alternative model systems to examine the mechanisms underlying valproic acid's action, and to ultimately develop improved treatments in which valproic acid is indicated, including epilepsy, bipolar disorder and migraine.

Next, we interrogate the underlying amino acid probabilities modeled by the most informative HMM and assume that a reduction in the amino acid probabilities (when comparing the wild-type to the mutant residue) indicates a potentially negative impact upon protein function whereas a gain in the amino acid probabilities indicates a more favorable substitution.

The molecular mechanisms and interactions underlying bile acid cytotoxicity are important to understand for intestinal and hepatic disease treatment and prevention and the design of bile acid-based therapeutics.

Consequently, we proposed that Prin2 was subjected to the underlying amino acid preferences in the different taxonomic domains.

Most interestingly, we found genes that provide interesting clues to the mechanisms underlying the acid soil tolerance of an Al-tolerant maize line.

In an effort to account for compositional biases we also recoded the underlying amino acid alignments into the six Dayhoff groups and inferred individual gene phylogenies using the Bayesian criterion [see additional file 4].

Measuring Q-tract lengths in affected individuals enables identification of putative repeat expansions outside the normal range, but more in depth characterization requires precise determination of the underlying amino acid and nucleotide sequences of individual alleles.

The accumulation of certain LCRs over time will depend on the intrinsic rate of slippage of the triplets encoding the underlying amino acid repeats, as well as the strength and mode of selection acting on the LCRs.

The major difference is that the Webserver predicts a NS as either D eleterious) or N eutral) according to LRT ori and ω, regardless of the quality of the underlying amino acid alignment.

An iterative cycle of model predications, experimental validation, and model refinement will therefore lead to an improved quantitative understanding of the interactive mechanisms underlying amino acid transfer as a biologic system in both health and disease.