(2) Zymogenic, or chief, cells are located predominantly in gastric glands in the body and fundic portions of the stomach.
At the base of the gland are the zymogenic (chief) cells, which are thought to produce the enzymes pepsin and rennin.
Loss of CA IX led to overproduction of mucus-secreting pit cells and depletion of pepsinogen-positive chief cells.
The pepsinogen that was secreted from gastric chief cells could be activated and transformed into pepsin in pH < 5.0, the pepsin could decompose the protein of chyme [20].
Stomachs of H/K-IFN-γ transgenic mice exhibited inflammation, expansion of myofibroblasts, loss of parietal and chief cells, spasmolytic polypeptide expressing metaplasia, and dysplasia.
Histological examination revealed a highly cellular tumoral proliferation, with a variable architecture, of which chief cells were immunoreactive for neuroendocrine markers and spindle-shaped cells positive for PS 100.
The homogeneous appearance is due to the homogeneous arrangement of chief cells within the lesion and the oval shape is due to growth along the longitudinally oriented tissue plane [7].
Hyperparathyroidism is most commonly caused by a benign proliferation of chief cells in single gland, and rarely MEN syndrome.
Two unique types of cells are present in the parathyroid gland: Chief cells, which synthesise and release parathyroid hormone.
In the glandular part of the stomach, CK1δ was highly expressed in the chief cells located at the base of the gastric glands while parietal cells were negative.
In contrast, MUC16 protein was absent in mesothelia as well as other cell types such as chief cells in the stomach (Figure 3).
