Sentence examples for by its ectopic expression from inspiring English sources

In contrast, reconstitution of CerS1 either by its ectopic expression or by treatment with chemotherapy induces C18-ceramide generation, leading to tumour suppression (Senkal et al, 2007).

Recent studies have shown that Meg3 splicing isoform was silenced and in pituitary tumor, cancer cell growth would be inhibited by its ectopic expression.

In the present article we explore the role in mammary cell biology of one transcription factor, namely NR4A1, by its ectopic expression in normal mammary epithelial cells and breast cancer cell lines.

Therefore, it is possible that while in the abp1-TD1 allele the expression of the BSM gene is rescued by its ectopic expression driven by 35S enhancers within the T-DNA, in the abp1-1 allele, where no such a mechanism exists, the expression of both genes may be disrupted.

CACNA2D3 in particular has a number of properties consistent with a tumour and/or metastasis suppressor function as demonstrated by its ectopic expression inhibiting cell growth and adhesion in gastric cancer cell lines, whereas knockdown with inhibitory RNA resulted in increased proliferation (Wanajo et al, 2008).

SCL was first identified by virtue of its ectopic expression as a target of t(1 14) chromosomal translocations in T-cell acute lymphoblastic leukemia [2].

Our experiments showed that, in cultured adipocytes, Ddit4 is inducible by p53 activation and its ectopic expression is sufficient to augment lipolysis.

EBNA1 is essential for the immortalization of primary B-lymphocytes by EBV infection [5], and its inhibition by siRNA depletion or by ectopic expression of dominant negative mutants induce apoptosis in EBV-infected cells [6], [7].

Once a candidate gene has been identified, its targeted manipulation can occur by ectopic expression (tissue specific or constitutive) or by gene suppression.

Restoring the myogenic potential of these cells by Pax7 downregulation or by ectopic expression of MyoD, promoted cell differentiation and fiber fusion and reversed muscle wasting.

We show here that perturbation of p89c-Mybex9b levels by ectopic expression or by specific downregulation modulates the proliferation, survival and IM sensitivity of BCR/ABL-transformed cells.