Cell types are characterized by different cell morphology and cellular functions which are defined by its specific pattern of gene expression thus, cellular differentiation can be considered as a switch or regulation of gene expression.
This notion was further confirmed by the finding that knockdown of endogenous COX-2 expression by its specific siRNA rendered Cl41 cells much more susceptible to cell apoptotic induction by arsenite.
Efficient downregulation of CD146 expression by its specific siRNA abolished netrin-1 (at 50 or 200 ng/ml) induced HUVEC proliferation, migration and tube formation, as well as VEGF signaling activation, whereas the inhibitory effect of netrin-1 at 2 000 ng/ml were not affected.
Since the physiological effects of IL-8 are mediated by its specific receptors CXCR1 and CXCR2, the expression of CXCR1 and CXCR2 by SUM149 cells were assessed by immunoblot.
Although TH2B is somewhat diverged from other vertebrate H2Bs, it falls well within the clade of animal replication –coupled H2Bs, and is primarily distinguished by its testis-specific expression.
pDCs are characterized by their specific expression of CD123, BDCA2, BDCA4 and ILT7 (Dzionek et al., 2000; Cao et al., 2006; Rissoan et al., 2002).
Compartment subdivision is induced primarily by the specific expression and activity of transcription factors that confer a compartment specific fate (reviewed in [4]).
In nonhuman adult mammals, myofibers are classified by the specific expression of myosin heavy-chain (MHC) isoforms into type I, type IIa, IIx/d and type IIb fibers [2].
