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In addition to the trade-off between systems identified under full commitment, the effect both accounting systems have on sequentially optimal second-period effort values determines which one is preferred.
It appears that there are two possible pathways for the entry/exit of type II inhibitors: one is the traditional ATP-channel and the other one is the allosteric-pocket-channel. Now, a question arises that which one is preferred.
Potentially revealing profiles could be obtained from examining species differences in how novel experimental (extractive foraging) tasks are explored and approached, how solutions are discovered and which ones are preferred, how flexibly multiple solutions are used and how much individual variation occurs, before proceeding to more detailed tests.
Their method will indeed detect both the four- and five-membered ring mappings, but it will not be able to indicate which one is actually preferred as their calculation of the transition state energy does not account for ring strain.
Only when the algorithms achieved the same rank in terms of accuracy, the faster one was preferred, which was guaranteed by adding time performance with a smaller adaptive weight.
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Terminologist and Q/A Analyst @ Translation Centre for the Bodies of the European Union