Sentence examples for tumor stabilization from inspiring English sources

And even some of those drugs offer only a few months at most of extra life or tumor stabilization despite prices that often reach thousands of dollars a month.

Six patients obtained a partial response; 7 others showed some tumor regression, 3 had tumor stabilization, and 13 disease progression.

However, while the multikinase and VEGFR2 inhibitor sorafenib provides tumor stabilization to a significant proportion of patients, resistance to therapy is inevitable and remains poorly understood.

The inability to sustain the initial tumor stabilization or regression induced by VEGF pathway blockers is arguably the most vexing problem now encountered by oncologists who care for patients with RCC.

Moreover, when the reimplanted tumors that had become resistant a second time were disaggregated and reimplanted into naïve hosts, they maintained their ability to respond to sorafenib a third time with a period of tumor stabilization of 9.7+/−3.8 days (n = 10) (Figure 1D).

Specifically, we note a period of tumor stabilization after initiation of therapy, defined as time required for the longest tumor diameter to increase by 20% (growth from 12 mm treatment start size to 14 mm) similar to RECIST criteria in patients.

In a Phase II study for metastatic melanoma (Table 3, AX) with low efficacy treatment, 172 long-term tumor stabilizations have been observed, but no objective responses was assessed.

With a drop of oxygen level (e.g., in tumors), stabilization of HIF1 α and HIF2 α (encoded by EPAS1) occurs, which is what results in induction of transcription of many genes encoding proteins involved in angiogenesis [ 70].

However, the latter could indirectly be excluded by further follow-up MR imaging studies, which demonstrated either tumor size stabilization or more often a continuously rising ratio of the volume of necrotic tumor areas to viable tumor tissue.

High HIF-1α protein expression in tumors reflects stabilization of HIF-1α protein due to the frequent presence of intratumoral hypoxia as well as increased synthesis of the protein caused by genetic alterations involving oncogenes (such as HER2/neu) and tumor suppressor genes (such as p53, PTEN, and VHL) and autocrine growth factor signaling in cancer cells [16], [17].

In contrast, frequency of mutation was significantly lower (3/14; 21.42%) (Additional file 3: Table S3) in p53 positive tumors exhibiting stabilization in less than 50% cells.