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Untreated tumors (n = 9) grew by 2 mm in 2.6+/−1.2 day while sorafenib treatment (n = 10) led to a 4.9+/−1.5 day period of relative tumor stability (P = 0.0029) (Table 1 and Figure 1 A and B).

These results are consistent with the recent clinical trials on melanoma using single agents that showed little anti-tumor effect other than only tumor stability in some cases [9], [15], [32].

We then evaluated tumor stability in human BC xenografts transplanted serially over several years, by comparing their profiles at early and late in vivo generations.

One way in which the barrier theory differs from the clonal diversification model as it was originally conceived (Fidler and Hart 1982) involves the role of heterogeneity in tumor stability.

Serial [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT scans from a melanoma patient with massive tumor burden demonstrates the potential clinical impact of tumor stability on maintaining performance status (Fig. 1B).

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Purpose: To evaluate intrafractional tumor position stability during computed tomography (CT -guided frameless stereotaCT -guidedtion therapy (SRT) framelessor liver cancerstereotacticd radiationCtherapying, with a fuSRTn oforT and lungar accelerator (FOCAliverit.

The effect of blood storage temperature and addition of a cell preservative on tumor cell stability was tested with tumor cell (GFP or DsRed MCF-7, DAPI labeled MCF-7 or unlabelled MCF-7 and SKBR-3) spiked blood samples.

To identify potent inhibitors of Wnt signaling, we conducted a primary screening in Wnt3a stably over-expressed HEK293W cells [24] with 600 compounds from library based on anti-tumor activity, stability and molecular mass.

We designed a nanocarrier system using protamine attached to polyethylene glycol (PEG) and evaluated the stability, tumor targeting, and tumor growth inhibition of the nanocarrier loaded with heparin derivatives.

A second goal was to compare this new peptide to an existing integrin-binding EETI-II mutant [22], [23], in terms of binding affinity, specificity, stability, tumor uptake and clearance, and tissue biodistribution for non-invasive molecular imaging applications.

Despite comparable low stability, tumor uptake was higher as found for the F-labeled derivative.

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