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Overall, the NET index was more sensitive than CgA in identifying neuroendocrine lesions and elevation was evident prior to image-based tumor confirmation in this patient.
Alteration in NET blood gene transcript levels prior to image-based tumor confirmation suggests this parameter may also have utility as an index of therapeutic efficacy.
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Therefore, the ability to biopsy the tumor and confirmation of the presence of these markers is an important step.
The cores were inserted directly into the recipient paraffin block in a grid arrangement, and one slide from each prepared TMA block was stained with hematoxylin-eosin for tumor tissue confirmation.
From the study of more than 800 miRNA in ER+ en ER− breast tumors and confirmation of our results in a large validation series, we identified a robust collection of 20 miRNAs significantly deregulated in ER+ compared to ER− breast cancers: 12 up-regulated and eight down-regulated miRNAs.
Patients who discontinued without a postbaseline tumor assessment or confirmation were considered nonresponders.
Possible applications of these MnO particles include slow release of Mn2+, tumor targeting, and confirmation of cell uptake [ 52].
Enrollment in the expansion phase of this study requires tumor biopsy for confirmation of FGFR1 status by fluorescence in situ hybridization (FISH).
Patients with breast cancer must have FGFR1 amplification and are required to provide archival or fresh tumor biopsy for confirmation of FGFR amplification, with a second biopsy planned on days 10 14.
Confirmation of tumor incidence will be confirmed at the end of the study by necropsy.
Histological confirmation of tumor cases from tissue registries has improved the quality of tumor registry data.
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