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"We are the central data and targeting entity," said Greg Speed, executive director at America Votes.
A single-chain Fragment variable (scFv) of the murine monoclonal antibody MAb-B43.13 MAb-B43.13CA125 in epitargetingvarian CA125r was previnusly depithelialexpressed, purified and provarianas a funcancerl targeting entity for biomedical applications.
The MTS peptide, MLRAALSTARRGPRLSRLL, a well-studied natural presequence from the mitochondrial-oriented protein aldehyde dehydrogenase (ALDH), was selected as the mitochondrial targeting entity.
Due to the missing tumor targeting entity, the observed tumor accumulations were faint and also a high unspecific accumulation of the compounds in nontarget organs such as liver, spleen, gut, lung, and blood was observed [ 41, 42, 44], limiting the usefulness of these compounds for in vivo tumor imaging.
Direct chemical conjugation to cells of a targeting entity, such as an antibody or a fragment derived from it is not straightforward and requires reaction conditions that may be toxic to cells and that could affect the properties of the entity attached.
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In general drug immunoconjugates are composed of targeting entities (mainly mAbs) chemically conjugated to a cytotoxic drug.
The combination of both targeting entities is likely to be of an added advantage for cancer therapeutics.
This technique, while showing excellent agreement with ensemble averages, is limited to fluorescing ligands and cannot be applied to many drug or targeting entities of interest.
Spectators are prone to applauding pranks that target entities they deem worthy of targeting.
He introduced vehicles that allowed Fed lending to target entities whose insolvency would pose severe risks to the system.
Activists could also target entities that take advantage of the commons energy companies, internet giants, pharmaceutical firms profiting from publicly funded research and hold sit-ins outside their doors until they pay into the fund.
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