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Virus replication delay (tau_{2}) represents the time necessary for the newly produced viruses to become mature and then infectious (see [10, 14, 22]).
Our model considers a four-dimensional diffusive virus infection model with intracellular delay, virus replication delay and Crowley-Martin infection rate.
The initial interpretation of a replication delay for Sakl0C-left relied on a relative under-representation of Sakl0C-left probes on microarray.
Consequently, DNA polymerase and RNA polymerase may collide while at work, resulting in transcriptional abortion, replication delay, and mutagenesis (Merrikh et al. 2012).
In a related study Kegel et al. [ 42] observed that inhibition of topoisomerase I and the build up of positive supercoiling caused replication delay in long but not short yeast chromosomes.
Similar(55)
Following viral DNA replication, delayed early and late viral genes are expressed which encode structural proteins for viral production.
Ongoing DNA replication delays meiotic DSB formation.
We reasoned that if PCNA-directed chromobodies can interfere with constitutive PCNA-dependent DNA replication, delayed neurogenesis and consequent morphological defects would be observed.
Given that Rad53 inhibits DDK in mitotically dividing cells and that DDK activates the meiotic DSB factor Mer2, we explored whether inhibition of pre-meiotic DNA replication delayed phosphorylation of Mer2.
We next assessed whether the formation of such aHCF and correlated replication delays might be associated to perturbed nuclear organization, as has been described in a Drosophila position effect model (Dernburg et al, 1996).
Because hmo1Δ strains are slow growing, showing slower progression throughout the cell-cycle (Lu et al, 1996), and PCNA modifications with SUMO and ubiquitin are expected to be sensitive to cell-cycle changes and replication delays (Hoege et al, 2002), we established a conditional degron system (hmo1-AID), in which Hmo1 depletion is induced by addition of auxin (Nishimura et al, 2009).
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