Sentence examples for replication problem from inspiring English sources

Factors that contribute to progressive telomere erosion include the inability of the replicative polymerase to completely duplicate linear chromosomes (the end replication problem), nucleolytic processing of telomeric ends, and sporadic telomere attrition due to defective telomere maintenance and repair mechanisms.

Telomeres lose 30 150 base pairs during each cell division (also known as the end replication problem) due to the inability of DNA polymerase to fully replicate the 3' end of the DNA strand.

The reasons for this difference are unclear but may reflect that fact that in eukaryotes, unlike prokaryotes, numerous origins are used to replicate each chromosome and eukaryotic chromosomes are linear, bringing an additional "end replication problem".

But his replication problem kept on getting worse.

This replication problem has become a crisis in the sense that researchers, ordinary citizens and policymakers no longer know what or whom to trust.

We formally study the data replication problem for these fragments by representing it as a variant of the bin packing problem and solve it using an integer linear programming solver.

Because conventional DNA polymerases are unable to complete the replication of the lagging strand, telomeres shorten at a slow pace with each replicative cell cycle (the so called end-replication problem; [ 19]).

In addition to the inhibition of inappropriate repair responses, fusions or recombinations, telomeres need to be fully replicated by the action of telomerase to prevent end-replication problem [6], [7], [8], [9].

With each cell division, telomeres shorten by about 60 base pairs due to the inability of DNA polymerase to fully replicate the chromosome end, a phenomena referred to as the end-replication problem.

During the process of DNA synthesis and cell division, telomeres are shortened as a result of the incomplete replication of linear chromosomes, which is called "end-replication problem".

In primary human cells, telomeres shorten with each round of cell division, primarily due to the end-replication problem of DNA polymerase.