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Among these, the proportion of insertions that identified in one replicate but not the other (the replication failure rate) is less than 1%.
In 2012 my anticipation of a 53% replication failure rate for psychology at large was published.
So the replication failure rate for psychology at large may be 80% or more overall.
Compared with other empirical studies, the failure rate of psychology seems to be in the same ballpark as replication failure rates in observational epidemiology, cancer drug targets and preclinical research, and animal experiments.
Finally, two recent reports show that marks of replication failure can be transmitted to daughter cells.
DNA DSBs can be induced by ionizing radiation and chemicals, or can occur as a consequence of replication failure.
Similar(46)
Apparent replication "failures" using approach (1) could thus relate to sample-to-sample differences in fine patterns of linkage disequilibrium and/or different amounts of information provided by markers with population-specific differences in allele frequencies.
Neither replications nor replication failures have been reported from other groups with longitudinal data.
(Pol IV also aids replication-fork repair during massive replication failures, but whether this was RpoS-dependent was not tested 30).
Increasing the number of licensed origins decreased the number of replication failures attributable to double-fork stalls (squares) at virtually the same rate whether the origins were efficient or inefficient.
Failure to adhere very closely to the regimens appears to be related to continued viral replication, treatment failure and the emergence of drug-resistant strains of HIV [ 13- 15].
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