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As a consequence, there is mutual activation of NOTCH signalling which maintains proliferation of this pool of uncommitted progenitors.
Hence, adaptation leads to a mutual activation of cells belonging to a common neuronal assembly reinforcing the idea of cellular mechanisms involving local cortical networks.
This study also showed that there is a mutual activation of HRas and PI3K, which is required to configure the bifurcation diagram with hysteresis as shown in Figure 2B.
The former module is represented by the mutual activation of Oct4 and Sox2, whereas mutual inhibition of the ME and ECT genes represents the latter module [18].
Additionally, as shown for septic patients the mutual activation of inflammation and coagulation results in an considerable increase of organ failure or dysfunction at multiple sites [ 33].
Thus, activation of Gr68a neurons is not sufficient to suppress courtship, possibly due to conflicting signals resulting from mutual activation of mechanosensory and chemosensory neurons (see 'Discussion').
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The mutual activation and repression of groups of genes in regulatory networks can lead to multi-stability allowing cells to attain different states [ 5, 21].
Second, plant CDPKs are a key regulator of innate immune responses to pathogen-associated molecular pattern stimulation [ 37, 38], and a mutual activation circuit consisting of CPK5 and NADPH oxidase RBOH facilitates rapid signal propagation in the plant [ 39].
In particular, independent of the specific mutual activation system chosen, the majority of the points lying in the second quadrant of the iSAToff iSATon plane have values of NAR in the "low noise region" for both ON and OFF states.
Recent studies of the pathogenesis of rheumatoid arthritis (RA) have revealed that both synovial fibroblasts and T cells participate in the perpetuation of joint inflammation as dynamic partners in a mutual activation feedback, via secretion of cytokines and chemokines that stimulate each other.
Initiation of apoptosis provides that mitochondria and caspases engage in a self-amplifying pathway of mutual activation.
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