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Exact(15)
Overall, we find that despite a large array of upstream mechanisms that feed into the Hippo pathway, the evidence suggests that all mechanisms of deregulation result in the common activation of the transcription factors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ).
The common activation of YAP in many different tumor types provides an attractive target for potential therapeutic intervention.
In addition to the cooperative action of VEGF and VEGF-C, their common activation of VEGFR/2 was reported to constitute an important way to mediate their functions.
In this case, cross-adaptation would presumably take place through common activation of second-messenger systems or of calcium trafficking [28].
In addition to the common activation of SOFC, there were activations that were particular to each category of visual stimulus (Fig. 2).
This overlapping temporal requirement supports the idea that AChR prepattern and axonal guidance are temporally coordinated through common activation of the unplugged/MuSK receptor.
Similar(45)
On a neuro-functional level the (horizontal segment of the) intraparietal sulcus (hIPS) has repeatedly been identified to be vitally involved when it comes to processing number magnitude information of different formats (symbolic digits: e.g., [ 10, 11]; dot patterns: e.g., [ 12, 13], see [ 14] for common activations of the IPS for symbolic and non-symbolic quantity).
This asymmetry might explain the lack of common activations to positive valence independent of arousal and further suggests that these 2 dimensions are not totally orthogonal at the neural level.
A common activation profile of 201 genes (Table S3) was induced in a stereotyped temporal pattern by the type I interferons (significantly more highly expressed by IFNα, IFNβ and IFNω treatment compared to mock); the consistency of this response is reflected by the high correlation scores between type I IFN treatments (Table S1).
To investigate common activation, irrespective of how whether the rules were cued or not, we performed a global null conjunction analysis (Friston et al. 2005).
The middle part of the postcentral gyrus, which is associated with face representation in SI [ 21- 23], showed significant common activation by all of the eye reflex areas.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com