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Such mutations will help to assess the importance of the interactions between talin and its various ligands in cell adhesion and migration.
Molecular profiles of the tumors, in particular K-ras mutations, will help guide the choice of second-line therapies in the future.
As molecular techniques have been increasingly applied to the rapid diagnosis of drug resistant M. tuberculosis, clarifying the fluoroquinolone resistance levels of M. tuberculosis that carry different gyrA and gyrB mutations will help optimize therapeutic regimens in clinical TB treatment.
Studies on naturally-occurring CDKN1B mutations will help us understand the link between p27 and neuroendocrine tumor predisposition, a prerequisite to offer in the future personalized care to the families carrying such mutations.
Work with other genetic mutations will help define the mechanisms of switching between DNA polymerases, a reaction that is currently proposed to involve post-translational modifications, including monoubiquitination of the sliding clamp PCNA protein at stalled DNA replication forks (Kannouche and Lehmann, 2004).
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The new rate of Y chromosome mutation will help refine the dates of key events in human evolution and migration, says Agnar Helgason of deCODE.
Knowing the mutation will help in understanding the aetiology of hydrocephalus and allow selection against the disease allele using a DNA test.
Every sport will help.
The whole-genome analyses in respective patients will identify many less frequent driver mutations, which will help identify potential drug targets in each patient, leading to more personalized cancer therapy.
Future evaluation of backcrossed lines with a reduced background mutation load will help clarify the effect of SBEIIa mutations on both starch content and seed weight.
Ultimately, it is likely that integration with data derived from single-cell mutation detection with bulk analysis (42) and validation using targeted single-cell mutation detection will help to resolve some of these issues.
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