Suggestions(5)
Exact(5)
If a segment of DNA encodes some essential molecule, mutations will tend to produce catastrophic damage.
The dynamics are expected to be influenced by the fact that females with repressive mutations will tend to be incompatible with infected males in the population, thus incurring an additional "cost" due to CI. Turelli has shown previously that selection on hosts tends to increase transmission rates in infected females, even in the presence of fecundity costs [21].
Indeed, compensatory mutations will tend to appear earlier within a passage and have time to spread in the population, because of their fitness advantage, before the reversion occurs.
In the absence of selection, fixation of random mutations will tend to decrease the strength of binding sties [ 19, 20], whereas purifying selection will tend to preserve binding sites, such that the effects of subsequent fixations will cancel out [ 18].
Because driver mutations are expected to occur early in the development of cancer cells, these mutations will tend to be present at higher frequencies in a cancer sample than passenger mutations, which occur later.
Similar(55)
In these cases a mutation will tend to become more common in a population through natural selection.
In malarious areas, carriers of this mutation will tend to have higher viability, leading to increased gene frequency until it is balanced by its loss in homozygotes who die before reaching sexual maturity.
This is consistent with our scoring system that mutations in driver genes will tend to have strong impact on protein functions.
Secondly, once the Wolbachia invasion has reached equilibrium within the host population, the effective population size of mtDNA will be reduced because mtDNA mutations in uninfected females will tend to be lost [ 48].
Moreover, starvation in both Chlamydomonas and S. cerevisiae is known to increase mutation rates [ 41, 42], which will tend to increase genetic variation.
However, infrequent mutations that provide a survival advantage will tend to clonally expand at the expense of neighboring cells in the tissue.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com