Sentence examples for mutations we considered from inspiring English sources

Since the aldh1a2um22 and aldh1a2i26 mutations are likely to be null mutations, we considered the most likely source of residual aldh1a2 activity to be maternally deposited mRNA.

To reduce the number of putative polymorphisms and facilitate detection of true mutations, we considered appropriate combinations of strains and devised ranking systems to penalize known sources of error.

When describing the distribution of fitness effects of successful beneficial mutations, we considered only a single mutation.

In searching for the causal mutations, we considered coding variants as well as variants in regulatory regions within 50 kb of known early-onset epilepsy genes (see Materials and Methods).

For the 40k strain, where a systematic approach is prohibited by the large number of mutations, we considered phenotypic, expression, and structural information along with prior literature, to make what is best described as an educated guess regarding which mutation might compromise fitness.

In order to identify de novo mutations, we consider that the best option is to maintain those sequences that match equally to more than one location, even though it could be a source of alignment errors due to homology between regions.

In addition to phase differences stemming from neutral mutations, we consider the variational principles of redundancy [ 23] and amplification [ 24] in explaining phase variation in overlapping genes.

Because complex I (cI) activity is severely affected by the mutation, we considered the alternative hypothesis that a decreased capacity for electron flow through cI alone underlies the tko 25t mutant phenotype, and that decreased capacity of complexes III and/or IV is immaterial, thus accounting for a failure of AOX expression to modify the phenotype.

One very common genetic aberration is an activating PI-3K mutation; we consider one that raises its catalytic activity by threefold.

We filtered out variants that were predicted to be tolerated/benign/unknown by both SIFT and PolyPhen-2 [ 1], and identified private mutations that we considered as candidate somatic mutations.

Almost all of 21U-RNAs could not be detected after prg-1 mutation, so we considered these 21U-RNAs were down-regulated.