Sentence examples for mutations to assess from inspiring English sources

Reverse transcript-polymerase chain reaction (RT-PCR) analysis was used, wherever possible, to investigate frameshift, nonsense and splicing mutations to assess their effect on GALC mRNA processing.

For example, patients can be screened readily for KRAS and V600E mutations to assess their eligibility to be treated with cetuximab or vermurafenib.

Metastatic samples harboring a particular mutation were compared against colorectal tumors lacking these mutations to assess for differences in levels of protein expression.

We conducted a large-scale screen of chemical- and transposon-induced mutations to assess the function of 40% of the Drosophila genome, including early essential genes and genes with pleiotropic phenotypes.

Having established conditions to maximize silencing activities of mature miRNAs from the transfected pri-mir-376a2 pri-mir-376a2 pri-mir-376a2their target site preferenconstructtrandfectodetermine-376a2 reportheiritargetsitects expreferencesARs and ADAR mutations to assess howeADARs affecotransfecteding actheities of resulting mireporter

Since previous NMR studies demonstrated that this mutation abolishes binding to methyl-CpGs without affecting the structure of the MBD or the rest of the protein (Free et al., 2001), we used this mutation to assess the necessity of methyl-CpG binding in both RTT and MECP2 duplication syndrome.

Preferably, the clinical studies would assess the effect of a fixed dose and regimen of AT1001 on α-Gal A levels in vivo, and would also include different patients that harbor the same mutation to assess the consistency of the intersubject mutant α-Gal A response.

Consequently, we have evaluated the performance of PolyPhen2, SIFT and MutationAssessor using balanced datasets (1451 neutral mutations and ten random selections of 1451 deleterious mutations) used to assess the performance of our method.

Phenotypic and genotypic analyses of stored plasma specimens were performed before and after the mutations occurred to assess NNRTI susceptibility.

Further studies are needed to establish the contributions of these mutations and to assess the roles of the newly identified antigenic proteins in the BCG Mexico 1931 phenotype.

However, these studies differ in the mutations used to assess the function of the GAP domain, which is likely to affect the results.