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Exact(7)
Even for selectively neutral mutations, the probability of ultimate fixation is only about one in 25 million for the large global yeast population.
For neutral mutations the probability of intra-individual fixation of the new variant was considered to be equal to its frequency in the heteroplasmic individual.
Because degenerative mutations greatly outnumber beneficial mutations the probability of neofunctionalization in small populations is rare whereas subfunctionalization is more likely to occur in these populations [ 33, 34].
For non-neutral deleterious mutations the probability of intra-individual fixation was considered to vary between zero and the frequency in the heteroplasmic individual.
Our empirical estimation of mtDNA coding region mutation rate, calculated taking into account the sex of individuals carrying new mutations, the probability of intra-individual fixation of mutations present in heteroplasmy and, to the possible extent, the effect of selection, is similar to that obtained using phylogenetic approaches.
Because spontaneous gene duplications and deletions originate at rates that are orders of magnitude higher than point mutations, the probability that copy-number changes in the same genes occur in independent populations is much greater than the same point mutation occurring in independent populations.
Similar(53)
If both, sire and maternal grandsire are heterozygous for the p.W215X-mutation, the probability of the resulting calf being homozygous is 12.5%.
Since q ii is the probability that the variant doesn't change by mutation, the probability that it does is given by 1- q ii.
For an unlinked second-site mutation, the probability of cosegregation of G418 resistance and colony color or size in three tetrads is (1/6) or 0.005.
As a result of the change of the selection parameters β i with the mutation bias, the probability that a mutation is accepted depends on the mutation bias.
To evaluate the impact of carrying a BRCA1 or BRCA2 mutation on the probability of experiencing premature natural menopause.
Related(20)
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