Sentence examples for mutations the risk from inspiring English sources

While much is known about the three common Ashkenazi BRCA1 and BRCA2 mutations, the risk they confer varies.

The average American woman has a 12- to 13-percent risk of developing breast cancer, but for women with certain genetic mutations, the risk can range between 50 and 80percentt for breast cancer and between 20 and 50percentt for ovarian cancer.

Prof Turnbull said: "Our studies on stem cells does express a cautionary note that it might not be 100% efficient in preventing transmission, but for many women who carry these mutations the risk is far less than conceiving naturally". Mitochondria are tiny structures which sit outside the nucleus of the cell and convert food into useable energy.

With MLH1 mutations, the risk is 54%; with MSH2, 21%; and with MSH6, 16%.

Currently, as stated in the Justice Clarence Thomas' decision, The average American woman has a 12- to 13-percent risk of developing breast cancer, but for women with certain genetic mutations, the risk can range between 50 and 80percentt for breast cancer and between 20 and 50percentt for ovarian cancer.

In contrast, we report a clear difference between ccRCC- and non-ccRCC-associated missense mutations; the risk of ccRCC in VHL disease is significantly associated with the degree of destabilization resulting from the mutations.

In women with BRCA1 or 2 gene mutations, the risks of pregnancy are not well established.

Where CRC were linked to somatic BRAF mutation, the risk was associated with long-term smoking [18].

For example, these annotations may describe the country of origin, the presence of a given resistance mutation, the risk group, the mode of transmission and so forth.

In breast cancer kindreds without a demonstrable BRCA mutation, the risk for breast cancer in female first degree relatives was about twice the risk in the general population.

Among women with a BRCA1 mutation, the risk of breast cancer increased by 1.2-fold for each first-degree relative with breast cancer before age 50 years (HR=1.21; 95% CI 0.94 1.57), and among women with a BRCA2 mutation, the risk of breast cancer increased by 1.7-fold for each first-degree relative with breast cancer (HR=1.65; 95% CI 1.00 2.71).