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We note that in these mutants the probability of UNC-40 localization and of axon outgrowth in the ventral direction is low.
In other words, for nonneutral mutants, the probability to invade is smaller in a spatial model than it is in the space-free Moran process.
In the mutants the probability of UNC-40 being present at a specific side of the neuron is altered; UNC-40 localizes with some probability to either the ventral, anterior, or posterior directions during initial axon formation.
Although the early production of dHb neurons appeared to be unaffected in tcf7l2 mutants, the probability that such neurons adopted a dHbl identity was significantly changed as assessed by the percentage of BrdU+ cells that later expressed the pku588 transgene.
We tested the robustness of these results by performing a sensitivity analysis over a wide range of key parameters, including the basic reproduction number, the rate of de novo resistance emergence, the rate of conversion between resistant mutants, the probability of developing clinical disease, and the relative transmissibility of the resistant strain with HTF [see additional file 1].
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Since the second barrier is weaker than the first for the Q3 mutant, the probability for the molecule to pass both barriers simultaneously is increased, thus resulting in a high percentage of single events".
Since the second and final energy barrier for complex dissociation is weaker than the first for the Q3 mutant, the probability for the molecule to pass both barriers simultaneously is increased, thus resulting in a higher percentage of single events.
The fact that RBP and BRP tightly co-accumulated in axonal aggregates of all these transport mutants strengthens the probability that BRP is always co-transported with RBP.
In higher plants, disrupted individual genes are usually obtained by screening of random mutants and the probability of altering a specific gene depends very much on the size of the target sequence.
Color indicates the presence of tendency of mutant or normal, which was showed as log10 value of the relative probability of mutant to the probability of normal (non-mutant) after Bayes calibration by FDR, ADO and a priori probability from normal tissue.
These models build on two separate parameters for a newly arisen mutant allele: the probability of mutation (effect of mutational bias or mutating tendency towards the mutated nucleotide) and the probability of fixation (effect of selection coefficients).
More suggestions(15)
shifts the probability
mutants the presence
mutants the differentiation
mutants the defect
mutants the ghost
mutants the defecation
mutants the chrna1
mutants the crystalline
mutants the level
mutants the model
mutants the development
mutants the concentration
mutants the percentage
mutants the ion
mutants the reactive
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