A number of independent studies [11], [12], [13], [14] have shown that in cases of EOC with BRCA1 mutations, the frequency of mutations of p53 is high, ranging from 70 90%.
The overexpression of PI4KA in HCC could not be explained by HNF1A mutations: the frequency of these mutations was low in our HCC series (<4%) [ 28].
Whether using the base VEGFR ePD model or those modified by mutations, the frequency of drug administration was characterized by both near-continuous and discontinuous drug administrations.
In contrast to KIT mutations, the frequency of BRAF mutations is generally low in mucosal melanomas and does not seem to vary significantly between different sites (Omholt et al, 2011).
Similar data has been reported in tumour cells exposed to increased number of hypoxic cycles in vitro, which resulted in increased number of DNA mutations, the frequency and types of which resembled those found in the same cells grown as tumours in vivo [ 6].
While both the single-stranded and scaffold-containing vector with C opposite the C8-dG-ABA adduct gave similar proportions of G → T and G → A mutations, the frequency of the latter increased dramatically when the adduct was located opposite the bubble scaffold.
