Sentence examples for mutations the prevalence from inspiring English sources

In contrast to the results obtained for mtDNA mutations, the prevalence of deletion was significantly lower in HCC tissue compared to noncancerous tissue (28 vs 95%; P<0.001).

The deepest reduction was observed for the loss-of-function mutations: The prevalence of low-frequency frameshift insertions (deletions) is only approximately 0.08 (∼0.05) of that in the reference compartment.

As the NCCN guideline currently recommends genetic counseling and genetic testing for any patient with high risk 10% or more of mutation, the prevalence of BRCA1/2 mutations in high-risk breast cancer patients without family history of breast or ovarian cancer noted in this study may play a key role for genetic testing criteria in Korean breast cancer patients with high risk of mutation.

Obviously, larger cohorts are needed for definitively answering the open questions about the frequency of WTX-gene mutations and the prevalence of mutations on the inactivated X-chromosome in female patients.

To assess the possible contribution of mtDNA haplogroup-specific mutations to the prevalence of longevity, we therefore performed a population-based case-control study in a Chinese Han population residing in Rugao, Jiangsu Province.

The R132H amino acid substitution is the most common form of IDH1 mutations with the prevalence of 90% among IDH1-mutant tumors.

The locational distribution of RASSF2 methylation was similar to that of K-ras/BRAF mutations, although the prevalence in each location was relatively low.

Nevertheless, some general rules exist: deletion mutations are always more frequent than insertion mutations, the genomic prevalence of indels declines with length, and this decline is faster for insertions than for deletions (Lynch 2007; Messer and Arndt 2007).

Future studies on the cancer risks associated with this mutation and the prevalence in different at-risk populations will be an important extension of this work to define the clinical significance.

Costs will vary depending upon the penetrance of the mutations detected and the prevalence of founder mutations in the population examined.

The gene's mutation rate and the prevalence of mutations do not seem to have been drastically altered by breed creation.