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Assuming random accumulation of mutations, the degree of divergency should then be age-related.
Considering that genetic drift is a stochastic process and does not discriminate the exact nature of mutations, the degree of bias toward deletions provides an explanation to the differential responses of eukaryotes and prokaryotes to elevated levels of drift.
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Importantly, each of the mutations also showed a striking decrease in nuclear localization in response to arsenite treatment, suggesting that the mutations increased the degree of nuclear export (Fig. 8A & B).
2. The relationship between the number of mutations and the degree of improvement toward promiscuous activities can be explained also by a probability distribution that describes the number of successes in a sequence of n draws from some finite population (e.g. hypergeometric distribution).
17AAG exerted the greatest effect on HNC cells that overexpress MDMX; however, 17AAG also induced growth suppression in mutant p53-bearing HNC cells, such as AMC-HN3 (heterozygous R282W mutation) and AMC-HN7 (heterozygous V157G mutation), although the degree of inhibition was lower than that induced in wtp53-bearing AMC-HN9.
The structural modifications caused by mutating Ala7 to Phe are the opposite of those created in M13V and M13V/K22M; notably, the A7F mutation decreases the degree of heme ruffling, whereas the M13V and M13V/K22M mutations increase the degree of ruffling.
The presence of accompanying deleterious mutations, the high degree of recurrence of the polymorphic mutations, and the occurrence of epistatic interactions generate a highly complex interference dynamics.
In contrast, the C-terminal domain E255A mutation increases the degree of apoE binding.
There is no clear correlation between the type of RPS19 mutation and the degree of hematological manifestation.
The reduction in tau protein by γ-secretase modulation with E2012 had differential effects depending on the specific mutation, with the degree of tau reduction correlated with the magnitude of the change in APP processing in each genotype.
The Fas DD V254N mutation increased the degree of correlated motion for these seven nonpolar residues in the CaM binding region relative to residues 290 316 (α5 and α6) (region VI) and the degree of anticorrelated motions relative to residues 256 280 (α3 and α4) (region VII).
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