Sentence examples for mutations that rendered from inspiring English sources

These plasmids encoded MUS81 with conservative mutations that rendered it refractory to siRNAs #9 and #10.

The ruvA and ruvB genes were discovered by mutations that rendered the E. coli cells sensitive to UV irradiation [ 77].

The two temperature-resistant mutants seem to carry suppressor mutations that rendered cells temperature-resistance and abolished L-glutamate overproduction.

For each DBRH tested, fitness gains were abolished when we introduced mutations that rendered the respective helicase domain catalytically inactive, suggesting that helicase and therefore RNA remodelling activities are essential for buffering.

Consistent with this, there was substantial phosphorylation of Ser in a human α2β2γ1 complex, and slight phosphorylation of Ser in a human α1β2γ1 complex, when they were incubated with MgATP alone; these effects were completely abolished by D157A mutations that rendered the complexes inactive, although Ser could still be phosphorylated by Akt in the inactive complex.

The absence of similar mutations in the other evolved populations suggests that they substituted other mutations that rendered this particular mutation unimportant.

Leu3 activity was elevated through overexpression and the introduction of a mutation that renders the protein constitutively active.

While recognizing that there are advantages to conditional- or regional-specific mutations; as a first step, we examined LTP in a line of mice containing a mutation that renders the PER2 protein non-functional (Zheng et al., 1999).

A recent study has provided compelling evidence that it activates AMPK in an indirect manner via an increase in AMP ATP and ADP ATP ratios using an engineered cell line expressing AMPK complexes bearing either the wild-type γ2 isoform or Arg531 → Gly mutation that renders γ2 complexes insensitive to the effects of ADP and AMP on phosphorylation [ 33].

Wright et al.[ 238] reported that the profile of ATH development was unaffected in Apoe−/− mice additionally carrying the lps d mutation that renders them unable to respond to bacterial lipopolysaccharide (LPS) – although LPS is only one of multiple stimulators of innate immunity.

Most retropseudogenes have undergone extensive mutational decay over evolutionary time, acquiring mutations that render them non-functional, such as large deletions and insertions (including retroelement insertions), frameshifts, and premature termination codons.