Sentence examples for mutations that accelerate from inspiring English sources

Although not typically mutated in pancreatic cancer, Pten was highly mutated in two recent screens for gene mutations that accelerate KrasG12D-driven pancreatic tumorigenesis.

5XFAD mice are amyloid precursor protein/presenilin-1 (PS1) double-transgenic mice that coexpress five familial AD mutations that accelerate plaque development.

For mVenus, a variant of the yellow fluorescent protein (YFP) that contains multiple mutations that accelerate the rate of protein folding and increase maturation at 37 °C, we expect this probability to be the same or higher.

In support of this, yHsp90 mutations that accelerate or decelerate ATPase rates result in significant growth defects and loss of client protein folding in vivo (Nathan and Lindquist, 1995; Prodromou et al., 2000).

Indeed, cells carrying Brca2 mutations that accelerate the disappearance of Rad51 foci also exhibit quicker entry into mitosis, whereas a mutation that slows the disappearance of the foci has an opposite effect.

The early days of molecular genetics showed, however, that you learn about the pathway to an end-result by studying mutations that block that pathway and that you may learn little or nothing from the mutations that accelerate it.

Further, mutations that accelerated release of WASP from filament-bound Arp2/3 complex proportionally accelerated branch formation.

Strong local and weak distant hotspots are caused by two mutation mechanisms that accelerate evolution in stressed cells.

After 12 to 24 days, genetic sequencing revealed that some resistant bacteria had developed mutations that had accelerated their growth rate to equal that of drug-sensitive strains.

It has been well documented that accelerated point mutations have occurred in the protein coding regions, and this adaptive mode of evolution might also be responsible for acquisition of new functions [ 65].

Although the mechanism of the exchange of segments in exons is unknown, it is apparent that these events play important roles in the evolution of these toxins, in addition to the role that accelerated point mutations in the exons plays in toxin evolution [ 10, 11, 14].