Missense mutations that disrupt LIS1 function block LIS1-mNudE binding.
About ten percent of all cancers harbor mutations that disrupt the spliceosome's precision performance, Madhani says.
Our observations indicate that most ubiquitin mutations that disrupt E1 activation also disrupt other functions.
We find that mutations that disrupt binding of the Fus2p/Rvs161p heterodimer to membranes affect Cdc42p ZCF localization.
Duchenne muscular dystrophy (DMD) is a hereditary disease caused by mutations that disrupt the dystrophin mRNA reading frame.
The topped mutant was previously isolated in a genetic screen designed to uncover mutations that disrupt primary motor axon guidance.
The structural integrity of these arrays correlates with cooperative RNA binding and RNA elongation and is sensitive to mutations that disrupt intermolecular contacts predicted by the polymerase structure.
Deletion or introduction of point mutations that disrupt the miR-466g target site attenuated miR-466g-directed suppression of luciferase activity.
When reconstructed into virus, mutations that disrupt lattice assembly exhibited growth defects, synthetic lethality or both, supporting the function of the oligomeric lattice in infected cells.
Logan J, Hiestand D, Daram P, Huang Z ,Muccio DD, Hartman J, et al. Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding.
Ghosh, S., Nunziato, D. A. & Pitt ,G. S. KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin.
