Sentence examples for mutations that activate from inspiring English sources

Most often genetic variations of Type-I tumors are KRAS and BRAF mutations that activate the mitogen-activated protein kinase (MAPK) signaling pathway [ 19– 219.

Codons 12 and 61 are 'hotspots' for mutations that activate their malignant transforming properties.

In c-H-ras, c-K-ras, and c-N-ras, codons 12 and 61 are 'hotspots' for mutations that activate their malignant transforming properties [1], [2], [3].

We therefore designed a genetic screen to search for novel cytoprotective features of the autophagy-lysosome pathway by looking for mutations that activate the pathway as a signaling or defense response.

Medulloblastomas, embryonal tumors arising in the cerebellum, commonly contain mutations that activate Wnt signaling.

The point mutations that activate the PIK3CA have been observed in some gliomas [ 18].

Luciferase assays were performed using a Tcf-E2 promoter reporter [ 11] in SW480 cells, which have an APC mutation that activates the Wnt signaling pathway, and in HeLa cells, which lack Wnt pathway activation.

Perhaps, instead of moving a valuable trait like resistance to cold from a fish to a plant, genetic engineers could achieve the same result by goading the plant into a mutation that activates genes for cold tolerance already present in its DNA.

E. coli AQ3625 strains, which harbor a sbcA gene mutation that activates the RecE homologous recombination pathway, can be used to efficiently ligate insert and vector DNA fragments with short-end homology regions in vivo.

Chief among the refining mutations was a promoter mutation that activated expression of the dctA C4-dicarboxylate:H+ symporter gene (Quandt et al., 2014).

In yeast, genetic screens were used to isolate mutations that constitutively activate the Ste2p receptor [24], [35].